Abstract:With the increase of urban migrants, self-employment has become the main form of employment. Thus, the comparative employment study of the self-employed and the employed workers draws an increasing attention from researchers. Based on the data of Guangzhou from the national migrants dynamic monitoring surveys in 2015, this paper has made a comparison of the urban medical security effects between the selfemployed and employed migrants by using the caliper matching of the propensity score matching and eliminating the sample selection bias of the self-employed workers. The result of the study shows that, under similar conditions, the urban medical security participation of the self-employed migrants is significantly lower than that of the employed workers and the self-employment has a negative effect on the urban medical security